I thought back, and ralised that the most fun I've had when it comes to drawing things on computers was with deluxepaint on my old Amiga. It was really easy editing a drawing pixel by pixel on it. I tried the wsame approach in photoshop, and well, it just feels way bulky to work it that way. Paint is... well... paint... so it's limited to say the least...
Here's the question again: Do you use some special software for pixel editing, which is your favorite? 
My drawing arsenal consists of 3 parts at the moment. Photoshop, Illustrator and Mandala Painter 3 (crazy fun, limited in usefulness though. )